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Salary: USD 136,000 - 170,000 / annual
Xaira Therapeutics is an AI-driven biotech startup focused on leveraging generative AI to transform drug discovery and development. The company develops AI models to design protein and antibody therapeutics against historically hard-to-drug targets, with headquarters in the San Francisco Bay Area, Seattle, and London.
As a Senior Scientist on the Protein Analytics team, you will play a crucial role in discovering and developing novel biotherapeutics through hands-on laboratory work. This is a lab-based position supporting the discovery and development of therapeutic molecules.
Key responsibilities include:
- Characterize antibodies in high-throughput manner via biolayer interferometry (BLI) and surface plasmon resonance (SPR) based biosensor platforms to determine binding, kinetics, and affinity information
- Screen antibodies and antibody-like molecules for off-target binding assessment via BVP ELISA or other poly-specificity/poly-reactivity assays
- Perform early developability assessment on antibody panels using SPR, DLS, DSF, SEC, and ELISA platforms
- Support fluorescence-based binding assays and assay automation workflows
- Analyze experimental data, curate results and reports, and present findings to cross-functional teams
- Maintain experimental records in an ELN
- Ensure compliance with laboratory safety protocols and contribute to lab organization and operations
Requirements:
- PhD degree in a relevant discipline (biophysics, biochemistry, structural biology, or related field) with 5+ years of industry experience, OR BS/MS degree with 10+ years of industry experience. Candidates with fewer years of experience are encouraged to apply with potential role level adjustment.
- Extensive experience in antibody screening including monoclonals, bispecific, and other antibody-like molecules
- Extensive hands-on experience with ELISA, BLI, and SPR-based platforms (Carterra, Biacore)
- Basic knowledge of protein production, purification, and characterization techniques (affinity, ion exchange, HIC, DLS, DSF, SEC)
- Proficiency in data analysis software (e.g., GraphPad Prism) and statistical tools
- Proactive, self-starter mindset with strong organizational, communication, and interpersonal skills
- Strong collaborative skills and interest in working in cross-functional teams and startup environment
- Excellent problem-solving and troubleshooting abilities
- Ability to work independently with accountability and meticulous attention to detail
