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Arvinas is a biotechnology company pioneering targeted protein degradation therapies using its proprietary PROTAC Discovery Engine platform. The company recently achieved the first FDA approval of a PROTAC protein degrader therapy in May 2026, marking a major milestone in the field.
We seek a Senior Research Scientist to serve as a key scientific contributor and knowledge leader in applied cellular neuroscience. This is a hands-on, lab-focused role driving neuroscience discovery programs forward through biochemical, immunocytochemical, and histochemical pharmacology readouts, with emphasis on primary cells and tissues of the central nervous system (CNS). High-content imaging (HCI) and histochemistry experience are strongly preferred.
The role requires collaboration in a matrixed environment with accountability to multiple project teams within Neuroscience. You will design and implement in vitro pharmacology readouts utilizing cellular biochemical, functional, and image-based endpoints, including ELISA/MSD, quantitative Western blot, HCI, and bioluminescence-based assay formats. You will provide technical and scientific leadership in immunohistochemical endpoints for CNS and other tissues, and serve as a core contributor to a collaborative HCI working group focused on best practices and robust solutions to assay design challenges.
Key responsibilities include: designing and implementing in vitro pharmacology readouts; providing technical leadership in immunohistochemical endpoints; generating timely data to support program decision-making; setting and maintaining high standards in data analysis and QC; driving internal dialogue around innovative data interrogation approaches; and interfacing with the automated biology organization to identify automation-amenable assay strategies.
This position is located at Arvinas headquarters in New Haven, CT and requires regular, hands-on, in-lab experimental work. The role offers the potential to develop and train other scientists across the research organization.
QUALIFICATIONS:
- B.S./M.S. with 12+ years of experience, OR Ph.D. with 2–5 years of experience in imaging, cellular and molecular biology, pharmacology, biochemistry, assay development, and biomolecular screening (neuroscience background with pharma/biotech experience preferred)
- Demonstrated ability as an assay designer and hands-on cell biologist to balance speed with rigor in a fast-paced, dynamic drug discovery environment
- Aptitude for systematic troubleshooting of biological assay systems
- Energetic, positive leader by example with capacity and enthusiasm to grow into a leader of a small team of scientists
- Must be legally authorized to work in the US without need for employer sponsorship now or at any time in the future
- Lab-based duties conducted in a lab environment; must be able (with or without accommodation) to lift/carry 15/30 pounds unassisted/assisted; work comfortably in controlled environment with biological, infectious, and hazardous materials; gown/degown PPE; use computer; engage in communications via phone, video, and electronic messaging; engage in problem-solving, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours
