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Salary: USD 121,000 - 141,000 / annual
Vaxcyte is a clinical-stage vaccine innovation company developing high-fidelity conjugate vaccines to protect against bacterial diseases including invasive pneumococcal disease, Group A Strep, and Shigella.
The Senior Associate Scientist will join the Research Department with primary focus on conjugation of polysaccharides and proteins for innovative conjugate vaccine development. This is an individual contributor role reporting to a Staff Scientist.
Key responsibilities include:
- Performing conjugation of polysaccharides and proteins using established chemical methods
- Developing, optimizing, and scaling up conjugation processes to improve yield, stability, and reproducibility
- Designing and executing experiments to evaluate physicochemical properties of conjugated vaccines (size, charge, antigenicity)
- Conducting analytical characterization using HPLC, SEC, MS, SDS-PAGE, UV-Vis, and other relevant techniques
- Collaborating with cross-functional teams (Process Development, Analytical Development, Quality Control)
- Documenting experimental results and maintaining detailed laboratory notebooks per company and regulatory standards
- Analyzing data, preparing technical reports, and presenting findings to internal and external stakeholders
- Staying current with scientific literature and emerging technologies in conjugate vaccine development
The role is onsite 5 days per week in San Carlos, CA.
Requirements:
- BS degree in Chemistry, Biochemistry, or related field with minimum 5 years industry experience, OR MS degree with minimum 3 years industry experience (other education/experience combinations considered)
- Proficiency in conjugation techniques involving polysaccharides and proteins
- Hands-on experience with analytical methods for biomolecule characterization
- Knowledge of chemistry principles related to covalent coupling and crosslinking chemistries
- Strong problem-solving abilities and attention to detail
- Excellent organizational and time-management skills for handling multiple projects
- Effective written and verbal communication skills
- Experience in vaccine development or biopharmaceutical research
- Familiarity with GLP/GMP environments and regulatory standards
- Prior work involving carbohydrate chemistry or protein modifications
