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Asimov is seeking a Scientist I/II in Viral Vector Process Development to join its Boston team. The company is building a mammalian synthetic biology platform to enable the design and manufacture of next-generation gene therapies.
In this role, you will drive execution across viral vector process engineering projects, including media and feed optimization, bioreactor process development at multiple scales (Ambr15, Ambr250, benchtop), and analytical assay development for lentiviral (LV) and adeno-associated viral (AAV) vectors. You will work closely with the Viral Vector and Biologics Cell Line Development teams, coordinate with external manufacturing partners on technology transfer, and create optimized workflows for cell line characterization and product quality assessment. You will author and review process development reports, support downstream processing and purification efforts, and represent the process development team on cross-functional initiatives.
The role reports to the Head of Process Development and offers the opportunity to work at a forward-thinking synthetic biology startup building the future of biological engineering.
REQUIREMENTS:
- Bachelor's degree in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or related field with 6–8 years of hands-on industry experience in viral vector process development for gene therapies; OR Master's degree with 3–4 years of experience; OR PhD with 0–2 years of experience.
- Mammalian cell culture expertise and aseptic technique proficiency; HEK293-based viral vector process development required.
- Hands-on experience with Ambr15, Ambr250, and/or benchtop-scale viral vector bioreactor processes.
- Analytical development and downstream purification experience highly preferable.
- Detail-oriented, highly organized, and experienced with standardized workflows and documentation practices.
- Expert-level proficiency with spreadsheets (Google Sheets, Excel); familiarity with Spotfire, Google Apps Script (JavaScript), and/or BigQuery preferred.
- Experience with DOE (Design of Experiments) software.
- Experience with electronic laboratory notebooks and good documentation practices.
- Cell line development experience and/or technology transfer of manufacturing processes in pharma desirable.
- CHO-based cell culture experience not required but preferable.
