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Salary: USD 125,000 - 139,902 / annual
Superluminal Medicines is a generative biology and chemistry company using deep biology, computational chemistry, machine learning, and proprietary data infrastructure to accelerate small molecule drug discovery. We are seeking an experienced Scientist to lead membrane protein production efforts and serve as a subject matter expert in membrane protein biochemistry.
You will drive the development and implementation of strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and biochemistry across drug discovery programs. This role combines hands-on laboratory work with scientific leadership opportunities to shape the company's platform and drug discovery projects.
Key responsibilities include:
- Design, produce, and optimize membrane protein constructs to increase success rates of small-molecule therapeutic discovery programs
- Develop high-throughput protein expression workflows using mammalian and insect cells, and purification methods ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM)
- Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects from hit finding through lead optimization
- Serve as a subject matter expert on membrane protein expression for internal and external project teams; evaluate and implement new technologies
- Document experiments in electronic lab notebooks and present data and strategies to internal and external audiences
Requirements:
- Bachelor's degree in Biochemistry, Molecular Biology, Biophysics, or related field with 8+ years of relevant experience; OR Master's degree with 5+ years of experience; OR Ph.D. with 2+ years of experience
- 2+ years of working experience in biotech or pharmaceutical industry
- Experience in molecular biology (cloning, construct design, mutagenesis)
- Experience in protein stabilization techniques (antibody fragments, fusion partners, mutagenesis)
Preferred qualifications:
- 5+ years of membrane protein expression and purification
- Experience in GPCR protein purification using FPLC (affinity, SEC)
- Experience with structural biology methods (data collection, Cryo-EM)
- Experience in laboratory automation in protein sciences and purification
- Experience with computational protein design tools (Rosetta, AI/ML-driven prediction)
