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Salary: USD 110,000 - 140,000 / annual
Basecamp Research is building frontier AI for therapeutic design, combining proprietary genomic datasets (BaseData—over 10B genes from 30+ countries) with machine learning to design cell and gene therapies, enzymes, and peptides. The company recently closed a $140M Series C and has offices in London and Boston.
You will join the Cambridge, MA team as Scientist I, Platform Innovation, reporting to the Head of Innovation Science. This role establishes a new platform innovation lab focused on gene editing and cellular engineering, specifically targeted cargo integration in dividing and non-dividing cells. You will work closely with Data Science and AI teams on discovery, validation, and engineering of novel gene editing tools.
Key responsibilities include:
- Contributing to strategy for design-build-test cycles of novel protein enzymes, with emphasis on discovery and validation of gene editing tools
- Building and screening plasmid libraries; developing cloning workflows for scale
- Quantifying editing outcomes using ddPCR, qPCR, flow cytometry, and NGS readouts
- Optimizing hits for activity and specificity using human primary cells and cell lines
- Contributing to scientific culture and establishing lab SOPs as a founding lab member
- Collaborating across teams on high-throughput screening platform development
Requirements:
- PhD in molecular biology, biochemistry, genetics, bioengineering, or related life sciences field; or MSc with equivalent hands-on laboratory experience
- Experience with gene editing, NGS assay development, protein engineering, and cell therapy
- Experience with high-throughput cloning methods and DNA construct production for cellular screening
- Proficiency in mammalian cell culture, transfection, and cell-line generation
- Knowledge of emerging gene editing technologies and on/off-target analytics for regulatory approval
- Expertise with DNA/RNA extraction, PCR, ddPCR, NGS library preparation, and QC
- Excellent communication skills with internal and external stakeholders
Advantaged by:
- Preclinical cell therapy program experience (in vivo or ex vivo)
- Flow cytometry expertise with antibody panels and fluorescent reporters
- Novel methods for gene editing off-target analytics using long/short-read sequencing
- Mechanistic understanding of gene editing tools (nucleases, base editors, transposons, recombinases)
- Experience integrating AI protein design tools with high-throughput wet lab screening
- NGS instrumentation fluency and bioinformatics tools knowledge
- Proactive problem-solving, adaptability, and high ownership mindset
