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Salary: USD 130,000 - 171,000 / annual
NewLimit is a biotechnology company developing medicines to treat aging by reprogramming the epigenome. The company has built leading experimental and AI systems to discover reprogramming medicines at scale, with initial products focused on restoring youthful metabolic, endothelial, and immune function.
You will design, formulate, and characterize targeted lipid nanoparticles (tLNPs) with antibody conjugates, Nanobodies, and scFv's to build NewLimit's targeting LNP platform. This is a hands-on bench role with direct ownership of targeting compositional and reaction design. You will work closely with the Delivery Sciences and biology teams to design and build a targeting lipids portfolio for the company's pipeline programs.
Key responsibilities include:
- Design and develop LNP compositions and conjugation chemistries for antibodies, nanobodies, scFv's, peptides, and other targeting moieties across multiple structural families, pushing the platform beyond current-generation materials for extra-hepatic targeting.
- Plan conjugation reactions and purification for these modalities with scale and final purity in mind from the outset, delivering against agreed project timelines.
- Test targeting lipids for the tLNP platform using a SAR-based approach to guide the next design cycle.
- Develop conjugation chemistries in-house or work with external partners to get targeted LNPs for particular target cells and build processes to support research teams testing tLNPs in vivo.
- Turn in vitro and in vivo data from discovery teams into concrete structural hypotheses and optimize tLNP compositions or targeting molecules used.
- Present experimental results and SAR conclusions, authoring protocols and technical reports.
Requirements:
- PhD in Pharmaceutical Sciences, Pharmaceutical Chemistry, Biochemistry, or related discipline plus 1–2 years of relevant work experience; OR MS with 5 years of focused tLNP design experience for liposomal or lipid nanoparticle applications.
- Strong skill set in design and formulation of new targeted LNPs, performed personally rather than with supervisor direction at each step.
- SAR-driven design, purification, and characterization of tLNPs and targeted moiety conjugated lipids, plus familiarity with AI-based SAR prediction tools for tLNP applications.
- Working knowledge of conjugation chemistries for attaching targeting moieties such as peptides, antibodies, nanobodies, and small-molecule ligands, including linker design and selection of suitable biorthogonal or site-specific handles.
- Practical purification skills spanning normal- and reverse-phase, size-exclusion chromatography, and preparative HPLC.
- Analytical characterization across LC-CAD, LC-UV, DLS, CE, bio-layer interferometry, and surface plasmon resonance with ability to deconvolute data to produce well-characterized tLNPs.
Nice to have:
- Familiarity with novel conjugation chemistries and reaction methods.
- Targeting moiety optimization experience for immune cells and endothelial cells.
- Exposure to scale-up process development, CMC, or tech transfer to a CDMO.
- Experience with data visualization and statistical analysis (R, Python, JMP).
