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Salary: USD 139,700 - 188,900 / annual
10x Genomics is seeking an experienced Scientist 2 to join the Single Cell Biology group and lead the development and optimization of single cell assays. This is a hands-on molecular biology role focused on developing, testing, and refining 10x single cell workflows while providing advanced troubleshooting support for internal teams and customers.
You will work in a multidisciplinary environment alongside colleagues in Molecular/Cell Biology, Chemistry, Fluidics, and Computational Biology. Key responsibilities include:
• Lead testing and troubleshooting of new assay sub-systems and existing single cell workflows, including sample processing, library preparation, sequencing, and data analysis
• Prepare high-quality NGS libraries and independently optimize established molecular biology protocols
• Contribute to conception and implementation of solutions to complex technical challenges and design decisions for new assay systems
• Master existing tools and defined methods, and lead their improvement
• Conceive of and develop new tools and methods to advance assay development capabilities
• Analyze and interpret experimental data to draw conclusions and determine next steps
• Generate intra-functional and cross-functional project sub-task plans and contribute to broader project plans
• Provide technical guidance to junior functional team members
• Partner with R&D, Support, and Marketing to drive assay development priorities and customer-facing troubleshooting
You will begin mentoring junior team members and work in a fast-paced, flexible startup environment.
REQUIREMENTS:
• B.S./M.S. or Ph.D. in chemistry, molecular biology, biochemistry, cell biology, or related field
• B.S./M.S. with 7+ years OR Ph.D. with 3+ years of relevant biotechnology or pharmaceutical industry experience
• Exceptional proficiency in molecular biology techniques: nucleic acid extraction, PCR/qPCR, NGS library preparation
• Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows
• Proven track record of using, optimizing, and troubleshooting molecular biology protocols
• Experience with experimental design and statistical data analysis
• Ability to perform complex multi-step experiments with detailed attention to planning, organization, hands-on technique, and record keeping
• Experience working with challenging clinical sample types (FFPE tissue, primary tumor cells, low-input samples)
• Strong collaboration and communication skills with ability to manage priorities and mentor others
• Desire to work in flexible, fast-paced startup environment
PREFERRED:
• Hands-on experience running 10x single cell assays across range of sample types
• Experience with product development lifecycle, new product introduction, and formal product testing (verification and validation)
• Experience mentoring junior scientists or research associates
