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Prolific Machines is developing an optogenetic platform that enables dynamic, tunable control over cellular functions for biotechnology applications. The company is backed by leading investors including Breakthrough Energy Ventures, Mayfield, and SOSV.
As a Research Associate in Cell Line Development Automation, you will contribute technically and scientifically to multiple projects while working on-site in Emeryville, CA. You will report to a Principal Scientist in the Cell Line Development department.
Key responsibilities include:
- Conducting experiments independently, collecting and analyzing data in a timely manner, and maintaining detailed documentation in electronic lab notebooks
- Working at the automation/CLD interface to establish efficient automation workflows (Tecan or Hamilton) for cell line development processes during seed train, production, or screening (Ambr or Beacon) operations
- Communicating effectively across teams, compiling and presenting data to different departments and forums
- Analyzing and providing critical data and figures to support presentations, patent applications, and publications
- Collaborating with the CLD team and other departments; contributing to lab maintenance and safety
- Developing and optimizing analytical methods while adhering to safety and operational standards
- On-site presence required as dictated by automation and CLD responsibilities and experimental needs
This is an individual contributor role focused on hands-on execution, instrumentation, and technical operations in a laboratory setting. Growth opportunities involve deepening technical expertise, expanding instrument proficiency, and taking on increasing operational responsibility within the Cell Line Development function.
QUALIFICATIONS:
- Education & Experience: Bachelor's degree with 2-5+ years of relevant industry experience, or Master's degree with 1-4+ years of relevant experience (RA II level); additional experience and independence expected at Senior RA level
- Designing and Executing Experiments: Ability to develop and propose experimental plans, conduct experiments independently, and troubleshoot analytical techniques and methodologies
- Work Style: Must precisely follow protocols, design and execute experiments independently, and manage multiple tasks in a fast-paced setting
- Communication Skills: Strong written and verbal communication skills essential for documentation and collaboration; proficiency with Microsoft Office (Word, Excel, PowerPoint) or Google Workspace (Docs, Sheets, Slides); ability to perform independent data analysis and generate meaningful conclusions
- Technical Experience: Experience with cell line development workflows (pool generation, clonal isolation, stability testing); experience with automation systems used in CLD processes (Tecan or Hamilton scripting experience a plus); exposure to high-throughput screening platforms (Beacon, Ambr, Octet, Cedex, or similar); experience with molecular cloning and molecular biology techniques (PCR, protein quantification); working knowledge of statistical analysis or design of experiments (DoE); comfort in dynamic, fast-paced R&D environments
- Nice to have: Familiarity with optogenetic systems, inducible promoters, or light-responsive protein engineering
- Personal attributes: Flexible and independent working attitude; ability to adapt to changing situations; strong eagerness to learn; well-developed communication, teamwork, and organizational skills; proactive approach to optimizing workflows
