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Salary: USD 81,000 - 89,000 / annual
Strand Therapeutics is a clinical-stage biotechnology company developing programmable mRNA therapeutics using its proprietary Signal Stack platform. The company integrates circular RNA, self-replicating RNA, targeted delivery, and genetic circuits to enable precise therapeutic control. Strand is advancing a pipeline focused on oncology and autoimmune disease, with lead program STX-001 showing preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors. The company has raised over $250 million and is headquartered in Boston, MA.
The Associate Scientist II of Manufacturing Scale-up and Analytics (MSAT) will support the execution, continuous improvement, and maturation of Strand's preclinical and clinical-stage manufacturing processes. This role reports to the Senior Scientist of MSAT and operates in a matrix-based environment across multiple teams.
Key responsibilities include:
- Support execution, continuous improvement, and maturation of preclinical and clinical-stage manufacturing processes
- Perform lab-scale RNA and lipid nanoparticle (LNP) production and analytical testing to evaluate process improvements, troubleshoot technology transfer and manufacturing challenges, improve process robustness, and support process scale-up
- Author technical protocols and reports documenting experimental procedures, results, and conclusions
- Collaborate with Process Development, Analytical Development, Automation, and Quality teams to advance manufacturing programs
- Partner with external technical counterparts to support ongoing technology transfer and manufacturing activities
The ideal candidate will be a strategic thinker with a leadership presence, enthusiasm for the company's mission, and a desire to tackle new challenges in a fast-paced, entrepreneurial environment.
Qualifications:
- B.S. or Advanced Degree in Biochemistry, Chemical Engineering, or related field
- 2+ years of working experience in RNA and/or LNP process improvement, manufacturing, and/or optimization at a biotech company
- Experience collecting, analyzing, and interpreting experimental data to evaluate process performance and support technical conclusions
- Experience with process development, scale-up, technology transfer, manufacturing support, and process troubleshooting; experience contributing to process characterization or later-stage development activities is a plus
- Experience optimizing and troubleshooting enzymatic reactions, chromatographic purification, tangential flow filtration (TFF), and other filtration methods for biologics
- Familiarity with ÄKTA systems and UNICORN control software is preferred
- Hands-on experience with RNA and/or LNP production processes and respective standard analytical methods (UV-Vis Spectroscopy, Gel Electrophoresis, ELISA, Dynamic Light Scattering, RiboGreen, etc.) strongly preferred
- Strong technical documentation and communication skills; ability to generate and maintain clear and detailed laboratory records and present experimental designs, data interpretation, and conclusions to cross-functional groups
